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Long-term use of oral corticosteroids can cause unwanted side effects, so it’s. The next day he noticed pain in his legs which intensified with muscle cramps and 24 hours later he presented to accident and emergency. Prednisone directly causes atrophy of muscle fibers (myopathy) leading to muscle weakness. This is a very common side effect of chronic (a. That can boost the body’s ability to produce muscle and prevent muscle breakdown. A heightened tendency for hair loss and male-pattern baldness; muscle aches
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